Electrophysiological interventions for inherited arrhythmia syndromes.

IInherited arrhythmia syndromes are electrical myopathies with genetic origins and risk of sudden death. They may present from infancy through adulthood, although the specific diseases have stereotypic but variable phenotypic onset and severity. There is clinical and genetic overlap among the syndromes, with variable penetrance and expressivity. Although underlying mechanisms of arrhythmogenesis may differ between syndromes, the electrophysiological (EP), pharmacological, and interventional options overlap. Specifics of the genetics, pharmacological therapies, and lifestyle modifications have been reviewed recently and are beyond the scope of this article, which focuses on interventional electrophysiology for inherited arrhythmias.